Role of Mucin 1 and Glycodelin A in recurrent implantation failure

Capsule:
The present study reveals that blood and tissue levels of Mucin 1 and Glycodelin A are much lower in women with recurrent implantation failure than in fertile women.

Authors:
Ercan Bastu, M.D., Mehmet F. Mutlu, M.D., Cenk Yasa, M.D., Ozlem Dural, M.D., Asli Nehir Aytan, M.D., Cem Celik, M.D., Faruk Buyru, M.D., John Yeh, M.D.

Volume 103, Issue 4, Pages 1059-1064

Abstract:

Objective:
To evaluate and compare the levels of Mucin 1 (MUC-1) and Glycodelin A (GdA) in precisely timed endometrial biopsies and blood samples taken from women with recurrent implantation failure, and women with proven fertility, in a control group.

Design:
Molecular studies in human blood and tissue.

Setting:
University hospital.

Patient(s):
Women with recurrent implantation failure and women with proven fertility.

Intervention(s):
Primary endometrial cells and blood samples during the implantation “window” (between day 7 and day 9 after the surge in luteinizing hormone).

Main Outcome Measure(s):
Expression of MUC-1 and GdA in the human endometrium and in blood during the implantation window were analyzed by enzyme-linked immunosorbent assay. Additionally, MUC-1 and GdA levels in tissue were analyzed by western blot during the same period.

Result(s):
Both blood and tissue measurements of MUC-1 and GdA were significantly lower in women with recurrent implantation failure than in fertile women during the implantation window. In addition, we found a highly significant correlation between blood vs. tissue measurements of both MUC-1 and GdA.

Conclusion(s):
The present study reveals that blood and tissue levels of MUC-1 and GdA are much lower in women with RIF, compared with those in fertile women. Receptivity can be evaluated with noninvasive blood sampling, rather than more-invasive endometrium sampling, as the blood and tissue measurements of MUC-1 and GdA are correlated.

  • globetrotter

    Is there any mechanism to increase levels of the protein

  • Hi, firstly thanks for the interest in our study. As you mentioned it would have been interesting to measure serum progesterone levels for this study. We haven’t done it for the existing study, but plan to do in the future.

  • Shvetha Zarek

    Given the recent interest in premature luteinization/premature progesterone rise and that glycodelin A is a progesterone regulated protein, did the authors evaluate serum progesterone levels in this cohort and correlate this to ART succcess?

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