A common gene variant in STK11 is associated with metabolic risk markers and diabetes during gestation

Capsule:
In pregnant women, the G allele for the rs8111699 variant in STK11 is associated with a more favorable metabolic phenotype and may protect against the development of gestational diabetes mellitus, particularly in heavier women.

Authors:
Judit Bassols, Ph.D., Ana Megia, M.D., Pilar Soriano-Rodríguez, M.D., Marta Díaz, Ph.D., Anna Prats-Puig, Ph.D., Magdalena Gifre, R.N., Inmaculada Simón-Muela, M.D., Sara Torrent, M.D., Anna C. Borrell, M.D., Joan-Carles Riera-Socasau, M.D., Ph.D., Joan Vendrell, M.D., Ph.D., Francis de Zegher, M.D., Ph.D., Lourdes Ibáñez, M.D., Ph.D., Abel López-Bermejo, M.D.

Volume 100, Issue 3, Pages 788-792, September 2013

Abstract:

Objective:
To assess whether the common rs8111699 (C528G) variant in STK11 is related to metabolic risk markers in pregnant women and to gestational diabetes mellitus (GDM).

Design:
Cross-sectional study.

Setting:
Hospital.

Patient(s):
A total of 561 pregnant women: 318 without and 243 with GDM (National Diabetes Data Group criteria).

Intervention(s):
None.

Main Outcome Measures(s):
rs8111699 variant in STK11 (Taqman technology). Fasting glucose, insulin (homeostatic model assessment of insulin resistance and β-cell function [HOMA-IR and -β]) and C-peptide assessed at 24–28 weeks’ gestation.

Result(s):
In non-GDM women, the G allele in rs8111699 was associated with lower HOMA-IR (CC: 1.3 ± 0.1 mIU/L; GG: 0.9 ± 0.1 mIU/L) and HOMA-β (CC: 165 ± 20 mIU/L; GG: 118 ± 10 mIU/L). In GDM women, the G allele was related to lower body mass index (BMI; CC: 27.9 ± 1.0 kg/m2; GG: 24.5 ± 0.6 kg/m2) and C-peptide (CC: 2.3 ± 0.1 ng/mL; GG: 1.6 ± 0.1 ng/mL). The GG genotype was less frequently observed in GDM women (18% vs. 26%), particularly in heavier GDM women (BMI > median: 14% vs. 28%).

Conclusion(s):
In pregnant women, the G allele for the rs8111699 variant in STK11 is associated with a more favorable metabolic phenotype and may protect against the development of GDM, particularly in heavier women.

  • Audrey Gaskins

    This is an interesting paper on a common genetic variant in relation to metabolic risk markers and development of GDM during pregnancy. While this finding needs to be replicated in other cohorts, it lends valuable insight into the mechanisms of GDM development. I had two questions when reading this article: 1) Why were women with poorly controlled GDM excluded? I would have been informative to see a sensitivity analysis including these women 2) How much of the effect observed do you think is mediated by BMI?

Translate »