A common gene variant in STK11 is associated with metabolic risk markers and diabetes during gestation

Capsule:
In pregnant women, the G allele for the rs8111699 variant in STK11 is associated with a more favorable metabolic phenotype and may protect against the development of gestational diabetes mellitus, particularly in heavier women.

Authors:
Judit Bassols, Ph.D., Ana Megia, M.D., Pilar Soriano-Rodríguez, M.D., Marta Díaz, Ph.D., Anna Prats-Puig, Ph.D., Magdalena Gifre, R.N., Inmaculada Simón-Muela, M.D., Sara Torrent, M.D., Anna C. Borrell, M.D., Joan-Carles Riera-Socasau, M.D., Ph.D., Joan Vendrell, M.D., Ph.D., Francis de Zegher, M.D., Ph.D., Lourdes Ibáñez, M.D., Ph.D., Abel López-Bermejo, M.D.

Volume 100, Issue 3, Pages 788-792, September 2013

Abstract:

Objective:
To assess whether the common rs8111699 (C528G) variant in STK11 is related to metabolic risk markers in pregnant women and to gestational diabetes mellitus (GDM).

Design:
Cross-sectional study.

Setting:
Hospital.

Patient(s):
A total of 561 pregnant women: 318 without and 243 with GDM (National Diabetes Data Group criteria).

Intervention(s):
None.

Main Outcome Measures(s):
rs8111699 variant in STK11 (Taqman technology). Fasting glucose, insulin (homeostatic model assessment of insulin resistance and β-cell function [HOMA-IR and -β]) and C-peptide assessed at 24–28 weeks’ gestation.

Result(s):
In non-GDM women, the G allele in rs8111699 was associated with lower HOMA-IR (CC: 1.3 ± 0.1 mIU/L; GG: 0.9 ± 0.1 mIU/L) and HOMA-β (CC: 165 ± 20 mIU/L; GG: 118 ± 10 mIU/L). In GDM women, the G allele was related to lower body mass index (BMI; CC: 27.9 ± 1.0 kg/m2; GG: 24.5 ± 0.6 kg/m2) and C-peptide (CC: 2.3 ± 0.1 ng/mL; GG: 1.6 ± 0.1 ng/mL). The GG genotype was less frequently observed in GDM women (18% vs. 26%), particularly in heavier GDM women (BMI > median: 14% vs. 28%).

Conclusion(s):
In pregnant women, the G allele for the rs8111699 variant in STK11 is associated with a more favorable metabolic phenotype and may protect against the development of GDM, particularly in heavier women.

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