The Expression of interleukin IL 6 IL 8 and their Receptors in Fallopian Tubes with Ectopic Tubal Gestation

Capsule:
Expression of interleukin (IL)-6, IL-8, and CXCR1 is significantly up-regulated in fallopian tubes with tubal gestation, while expression of CXCR2 and IL-6Ra is not changed in comparison with normal fallopian tubes.

Authors:
Erin Balasubramaniam, M.Sc., Susan Van Noorden, B.Sc., Mona El-Bahrawy, Ph.D.

Issue 98, Issue 4, Pages 898-904, October 2012

Abstract:

Objective:
To investigate the level of expression of the cytokines IL-8 and IL-6 and their receptors in fallopian tubes with tubal ectopic gestation.

Design:
Immunohistochemistry was used to study the expression of IL-8, CXCR1, CXCR2, IL-6 and IL-6 receptor alpha in fallopian tubes with tubal ectopic gestation in comparison to normal fallopian tubes.

Setting:
Hospital.

Patients:
We studied fallopian tubes from 50 patients with tubal ectopic gestation and normal fallopian tubes from 25 patients who had hysterectomy and bilateral salpingo-oopherectomy for uterine or ovarian lesions.

Interventions:
The expression of the chemokines/cytokines and their receptors was evaluated by immunohistochemistry (IHC).

Main Outcome Measure(s):
Level of expression and tissue distribution of the different antigens.

Results:
IHC results showed that the expression levels of IL-6 and IL-8, as well as CXCR1 were significantly up-regulated particularly near the implantation site in FTs with tubal gestation (p-values 0.001, 0.01 and 0.001 respectively), while the expression levels of CXCR2 and IL-6Rα were not changed in comparison to normal FTs.

Conclusions:
The results suggest a role of IL-6, IL-8, and CXCR1 in the pathophysiology of tubal ectopic gestation.

Translate »