The Expression of interleukin IL 6 IL 8 and their Receptors in Fallopian Tubes with Ectopic Tubal Gestation
Expression of interleukin (IL)-6, IL-8, and CXCR1 is significantly up-regulated in fallopian tubes with tubal gestation, while expression of CXCR2 and IL-6Ra is not changed in comparison with normal fallopian tubes.
Erin Balasubramaniam, M.Sc., Susan Van Noorden, B.Sc., Mona El-Bahrawy, Ph.D.
Issue 98, Issue 4, Pages 898-904, October 2012
To investigate the level of expression of the cytokines IL-8 and IL-6 and their receptors in fallopian tubes with tubal ectopic gestation.
Immunohistochemistry was used to study the expression of IL-8, CXCR1, CXCR2, IL-6 and IL-6 receptor alpha in fallopian tubes with tubal ectopic gestation in comparison to normal fallopian tubes.
We studied fallopian tubes from 50 patients with tubal ectopic gestation and normal fallopian tubes from 25 patients who had hysterectomy and bilateral salpingo-oopherectomy for uterine or ovarian lesions.
The expression of the chemokines/cytokines and their receptors was evaluated by immunohistochemistry (IHC).
Main Outcome Measure(s):
Level of expression and tissue distribution of the different antigens.
IHC results showed that the expression levels of IL-6 and IL-8, as well as CXCR1 were significantly up-regulated particularly near the implantation site in FTs with tubal gestation (p-values 0.001, 0.01 and 0.001 respectively), while the expression levels of CXCR2 and IL-6Rα were not changed in comparison to normal FTs.
The results suggest a role of IL-6, IL-8, and CXCR1 in the pathophysiology of tubal ectopic gestation.