Cell derived microparticles and vascular pregnancy complications A systematic and comprehensive review

Capsule:
Pregnancy showed a cMP increase. Differences in numbering and types of cMP in normal pregnancy, RM and PE have been demonstrated. Endothelial-derived cMP are increased in patients with antiphospholipid antibodies.

Authors:
Jaume Alijotas-Reig, Ph.D., Carlos Palacio-García, M.D., Ph.D., Elisa Llurba, M.D., Ph.D., Miquel Vilardell-Tarrés, M.D., Ph.D.

Volume 99, Issue 2, Pages 441-449, February 2013

Abstract:

Objective:
To assess current studies on the relationship between cell-derived microparticles (cMP) and recurrent miscarriages (RM) and preeclampsia (PE), and review the relationships between cMP and inflammatory and clot pathways, antiphospholipid antibodies (aPL), cytokines and pregnancy complications.

Design:
A comprehensive review of the literature from January 2000 to January 2012.

Setting:
Vall d’Hebron University Hospital.

Patient(s):
Women with recurrent miscarriages or preeclampsia, healthy non-pregnant and healthy pregnant women.

Intervention(s):
None.

Main Outcome Measure(s):
To compare cMP numbers and types among groups.

Result(s):
Platelet and endothelial cMP are increased in women with normal pregnancies compared with non-pregnant healthy women. Only five case-control studies regarding cMP and RM and 16 on cMP and preeclampsia were found to match our objective. Three of 5 articles referring to RM showed differences in cMP numbering, and 13 of 16 on cMP and preeclampsia showed differences in some type of cMP compared with controls.

Conclusion:
cMP were raised in normal pregnancy. Recurrent miscarriage appears to be related to endothelial and platelet cell activation and/or consumption. An increase in almost all cMP types was observed in PE. A relationship between cMP and endothelial activation and proinflammatory status seems to exist.

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