Cell derived microparticles and vascular pregnancy complications A systematic and comprehensive review

Pregnancy showed a cMP increase. Differences in numbering and types of cMP in normal pregnancy, RM and PE have been demonstrated. Endothelial-derived cMP are increased in patients with antiphospholipid antibodies.

Jaume Alijotas-Reig, Ph.D., Carlos Palacio-García, M.D., Ph.D., Elisa Llurba, M.D., Ph.D., Miquel Vilardell-Tarrés, M.D., Ph.D.

Volume 99, Issue 2, Pages 441-449, February 2013


To assess current studies on the relationship between cell-derived microparticles (cMP) and recurrent miscarriages (RM) and preeclampsia (PE), and review the relationships between cMP and inflammatory and clot pathways, antiphospholipid antibodies (aPL), cytokines and pregnancy complications.

A comprehensive review of the literature from January 2000 to January 2012.

Vall d’Hebron University Hospital.

Women with recurrent miscarriages or preeclampsia, healthy non-pregnant and healthy pregnant women.


Main Outcome Measure(s):
To compare cMP numbers and types among groups.

Platelet and endothelial cMP are increased in women with normal pregnancies compared with non-pregnant healthy women. Only five case-control studies regarding cMP and RM and 16 on cMP and preeclampsia were found to match our objective. Three of 5 articles referring to RM showed differences in cMP numbering, and 13 of 16 on cMP and preeclampsia showed differences in some type of cMP compared with controls.

cMP were raised in normal pregnancy. Recurrent miscarriage appears to be related to endothelial and platelet cell activation and/or consumption. An increase in almost all cMP types was observed in PE. A relationship between cMP and endothelial activation and proinflammatory status seems to exist.

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