Follicle-stimulating hormone receptor gene polymorphisms are not associated with ovarian reserve markers

Capsule:
This study evaluated the association between FSH receptor gene variants and current markers of ovarian reserve. No associations of FSH receptor genotypes with markers of ovarian reserve were detected.

Authors:
Lamiya Mohiyiddeen, M.R.C.O.G., William G. Newman, F.R.C.P., Ph.D., Helen McBurney, B.Sc., Betselot Mulugeta, M.Sc., Stephen A. Roberts, Ph.D., Luciano G. Nardo, M.D.
Volume 97, Issue 3 , Pages 677-681, March 2012

Objective:
To evaluate the association between variants in the FSHR receptor (FSHR) gene and current markers of ovarian reserve (antimüllerian hormone, antral follicle count, FSH).

Design:
Prospective observational study.

Setting:
Tertiary referral center for reproductive medicine.

Patient(s):
Women (n = 421) undergoing their first cycle of controlled ovarian stimulation for IVF.

Intervention(s):
Baseline pelvic ultrasound and blood tests were taken on day 2–3 of the cycle for assessment of baseline hormones and for DNA extraction. Genotypes for FSHR p.Asn680Ser and p.Thr307Ala variants were determined using TaqMan allelic discrimination assays.

Main Outcome Measure(s):
Association of FSHR single nucleotide polymorphisms with markers of ovarian reserve.

Result(s):
There was no evidence of any difference in basal FSH, antimüllerian hormone, or antral follicle count between the patients with different genotypes, with or without an adjustment for age or body mass index.

Conclusion(s):
No associations of FSHR genotypes with markers of ovarian reserve were detected in our cohort.

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