Variants of the WNT7A gene in Chinese patients with müllerian duct abnormalities
One novel synonymous variant and three known single-nucleotide polymorphisms in WNT7A were identified in 191 Chinese patients with m€ullerian duct abnormalities.
Yujie Dang, M.Sc., Yingying Qin, M.D., Ph.D., Rong Tang, M.D., Ph.D., Yulan Mu, M.D., Ph.D., Guangyu Li, M.Sc., Mingdi Xia, M.Sc., Zi-Jiang Chen, M.D., Ph.D.
Volume 97, Issue 2 , Pages 391-394.e1, February 2012
To search for WNT7A gene mutations in a cohort of 191 Chinese Han patients with müllerian duct abnormalities (MDAs).
Phenotypic and mutational study.
A total of 191 Chinese Han patients with MDAs and 192 healthy control individuals.
Genomic DNA extracted from blood samples, all coding regions amplified by polymerase chain reaction (PCR) then directly sequenced to screen variants.
Main Outcome Measure(s):
The sequence analysis revealed one novel synonymous variant and three known single-nucleotide polymorphisms (SNPs).
The results indicate that mutations in the coding sequence of WNT7A are not responsible for müllerian duct abnormalities in the Chinese population.