Effect of maternal height and weight on risk of preterm birth in singleton and twin births resulting from in vitro fertilization: a retrospective cohort study using the Society for Assisted Reproductive Technology Clinic Outcome Reporting System

Capsule:
Overweight significantly increases the risk of very early preterm and very preterm births in twins conceived by IVF.

Authors:
Richard P. Dickey, M.D., Ph.D., Xu Xiong, M.D., Dr.P.H., Rebekah E. Gee, M.D., M.P.H., Gabriella Pridjian, M.D.
Volume 97, Issue 2 , Pages 349-354, February 2012

Objective:
To examine the effect of height, weight, and body mass index (BMI) on the risk of preterm birth of singleton and twin pregnancies conceived by vitro fertilization (IVF).

Design:
Retrospective cohort study using 2006–2008 data from the Society for Reproductive Technology Clinic Outcome Reporting System (SART CORS).

Setting:
SART-associated assisted reproductive technology programs.

Patient(s):
56,556 singleton and 23,804 twin live births resulting from fresh nondonor IVF cycles.

Intervention(s):
None.

Main Outcome Measure(s):
Rates of very early preterm (VEPTB; 35 kg/m2) twins were associated with a threefold increased risk of VEPTB (6.1% vs. 2.0%) and a twofold increased risk of VPTB (11.5% vs. 5.9%) compared with women of normal weight (BMI 18.4–24.9 kg/m2).

Conclusion(s):
Obesity and short stature significantly increase the risk of VEPTB and VPTB in twins conceived by IVF.

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