A pituitary adenoma secreting follicle-stimulating hormone with ovarian hyperstimulation: treatment using a gonadotropin-releasing hormone antagonist

Capsule:
Treatment with gonadotropin-releasing hormone antagonist improved the clinical, laboratory and ultrasonographic parameters of a pituitary adenoma secreting follicle-stimulating hormone associated with ovarian hyperstimulation which persisted after transsphenoidal surgery.

Authors:
Heraldo Mendes Garmes, M.D., Ph.D., Oswaldo Rocha Grassiotto, M.D., Ph.D., Yvens Barbosa Fernandes, M.D., Ph.D., Luciano de Souza Queiroz, M.D., Ph.D., José Vassalo, M.D., Ph.D., Daniel Minutti de Oliveira, M.D., Cristina Laguna Benetti-Pinto, M.D., Ph.D.
Volume 97, Issue 1 , Pages 231-234, January 2012

Objective:
To describe the management of a patient with a pituitary adenoma secreting follicle-stimulating hormone (FSH) associated with ovarian hyperstimulation who was treated with a gonadotropin-releasing hormone (GnRH) antagonist.

Design:
Case report.

Setting:
University teaching hospital.

Patient(s):
A woman of reproductive age with secondary amenorrhea and ovarian hyperstimulation due to a pituitary adenoma secreting FSH, which persisted after transsphenoidal surgery.

Intervention(s):
Clinical treatment with a GnRH antagonist.

Main Outcome Measure(s):
A decrease in serum estradiol levels.

Result(s):
During the treatment period, ovarian hyperstimulation decreased as shown by a reduction in estradiol levels and an improvement in the patient’s clinical condition and in the ultrasonography parameters.

Conclusion(s):
The GnRH antagonist was found to be effective for the short-term treatment of ovarian hyperstimulation secondary to a pituitary adenoma secreting FSH, thus representing a therapeutic option that should be taken into consideration in such cases.

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