Uterus transplantation: animal research and human possibilities

Capsule:
We describe uterus transplantation research conducted in the animal model and explore its introduction in the human model.

Authors:
Mats Brännström, M.D., Ph.D., Cesar Diaz-Garcia, M.D., Ash Hanafy, M.D., Michael Olausson, M.D., Ph.D., Andreas Tzakis, M.D.
Volume 97, Issue 6 , Pages 1269-1276, June 2012

Abstract:
Uterus transplantation research has been conducted toward its introduction in the human as a treatment of absolute uterine-factor infertility, which is considered to be the last frontier to conquer for infertility research. In this review we describe the patient populations that may benefit from uterus transplantation. The animal research on uterus transplantation conducted during the past two decades is summarized, and we describe our views regarding a future research-based human attempt.

  • Ivo Brosens

    The most suitable animal for evaluating the unique vascular response of the uterus to pregnancy in terms of adequate placentation includes the apes, such as the chimpanzee, and therefore the question is whether the outcome of pregnancy has been evaluated after chimpanzee or other apes uterus transplantation ? This information seems to be essential before any human attempt is performed. Experiments on animals that have not hemochorial placentation with uterine trophoblast invasion cannot provide any valuable information.

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