Repeated implantation failure: clinical approach

Repeated implantation failure should be assessed for different causes and treated accordingly.

Alex Simon, M.D. and Neri Laufer, M.D.
Volume 97, Issue 5, Pages 1039-1043, May 2012

Successful embryo implantation depends on a well-functioning endometrium as well as a normal healthy embryo. This process might be hampered if either of these variables is defective. Repeated implantation failure (RIF) is diagnosed when good-quality embryos repeatedly fail to implant after transfer in several IVF treatment cycles. The causes of RIF originate with either the mother or the embryo. The authors discuss factors that are associated with RIF and address various treatment options.

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